With the flexiblity of Amazon Web Services (AWS) you can create many servers in minutes. This is great from a scaling up point of view. Your PR department have just informed you that a segment about your product is about to appear on national TV. You expect a spike in traffic, but its okay because of the preperation work and auto-scaling.
One of the hardest limits to monitor and manage, is the AWS API Limit. This is a sliding scale limit of requests per second, and is there to protect AWS from request spikes or storms. This can be mitigated by retries, or you may need further investigations as to what may be causing the API calls.
Let me know your experiences with the Amazon Web Services API and account limits.